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Clinical and critical factor can distinguish effectively LADA and 2 model diabet
From;    Author:Stand originally
Immunity of oneself of adult evening hair is diabetic (LADA) is a kind of manhood comes on, pancreas islet antibody is electropositive and original need not what insulin treats is diabetic. As 1 model a diabetic inferior model, because it makes progress very easily to be depended on to insulin, because this inchoate diagnostic LADA has very important sense. So, what kind of manhood comes on does the diabetic need to accept pancreas islet antibody to detect? Australian Fourlanos reported a few days ago, have ≥ element of 2 LADA clinical risk person it is the LADA Gao Wei that need accepts pancreas islet antibody to detect crowd. [Diabetes Care 2006, 29(5) ∶ 970)

Fourlanos undertook one reviews a gender to consider first, take off carboxyl enzymatic antibody with glutamic acid (111 of the 102 LADA patient of GADA) positive and GADA negative 2 model the diabetic is research target (the age all is 30~75 year old) , come on to its index of the acute symptom of time, tall blood sugar, weight (BMl) and individual of oneself immunity disease and familial history etc undertook comparative. The clinical performance that any occurrence rate adds LADA group significantly considers as " the clinical and critical factor that has divisional value " . Basis " the clinical and critical factor that has divisional value " gross can be calculated give every individual " LADA is clinical and dangerous notch " .

The result shows, the occurrence of 5 clinical expression leads LADA group remarkable prep above 2 model diabetic group, it is respectively come on age <50 year old (the acute symptom of P<0.0001) , tall blood sugar (disease of immunity of P<0.0001) , BMI<25 Kg/m2(P=0.0004) , oneself history (P=0.011) and oneself immunity disease are familial history (P=0.024) .

Next, the sex of the look up before undertaking again such as Fourlanos studies, bring into the diabetic of 130 new diagnose in all, in order to is evaluated " LADA clinical danger notchs " whether to conduce to check giving LADA patient.

The result shows, 2 are put in ≥ afore-mentioned " the clinical and critical factor that has divisional value " (namely LADA is clinical and dangerous notch ≥ 2) , the sensitivity that forecasts LADA and particularity are respectively 90% with 71% , and LADA clinical danger notchs the negative of 1 forecasts ≤ the value is 99% .

Study clew: Patient of ADA of Huo Suo 齃 has been put when diagnose be in 2 or 2 above " the clinical and critical factor that has divisional value " . The existence of these clinical and critical factors can distinguish effectively LADA and

2 model diabetic, what promote LADA thereby is inchoate diagnose and inchoate cure, improve its prognosis.

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